Anti-HSP90 alpha/beta Purified
Product Sizes
0.025 mg
£159.00
11-533-0.025MG
0.1 mg
£278.00
11-533-0.1MG
About this Product
- SKU:
- 11-533
- Application:
- IHC-Paraffin, Western Blot
- CE/IVD:
- RUO
- translate.label.attr.clone:
- MBH90AB
- Concentration:
- 1 mg/ml
- Extra Details:
- Hsp90 (heat shock protein 90) is one of the most abundant chaperones in the cytosol of eukaryotic cells. It interacts with various proteins, including protein kinases and transcription factors, and either facilitates their stabilization and activation or directs them for proteasomal degradation. Hsp90 thus affects multiple signaling pathways and biological processes and modulation of this single target offers the prospect of simultaneous intervence to various key points of oncogenic transformation. Hsp90 operates as a dimer in a conformational cycle driven by ATP binding and hydrolysis. There are two isoforms, alpha and beta, of vertebrate Hsp90. Whereas Hsp90 beta is expressed constitutively to a high level, Hsp90 alpha is stress-inducible and is overexpressed in many cancerous cells.
- Immunogen:
- Peptide corresponding to the sequence EEVHHGEEEVEC within N-terminal part of human Hsp90.
- Isotype:
- IgG1
- Reactivities:
- Bovine, Human, Mouse
- Shipping Conditions:
- Blue Ice
- Specificity:
- The antibody MBH90AB recognizes the epitope EEEVE within N-terminal part of ubiquitously expressed Hsp90 alpha and Hsp90 beta intracellular proteins with calculated Mw of 84.7 kDa and 83.3 kDa, respectively, however, migrating as 90 kDa bands under reducing SDS-PAGE conditions.
- Storage Conditions:
- 2-8[o]C Do not freeze.
- Supplier:
- Exbio
- Type:
- Antibody
