Anti-SHIP1 Purified
Product Sizes
0.025 mg
£121.00
11-524-0.025MG
0.1 mg
£202.00
11-524-0.1MG
About this Product
- SKU:
- 11-524
- Application:
- Flow Cytometry, Immunocytochemistry, Western Blot
- CE/IVD:
- RUO
- translate.label.attr.clone:
- SHIP-01
- Concentration:
- 1 mg/ml
- Extra Details:
- SHIP-1 (SH2 domain containing inositol phosphatase-1) is a 5'inositol phosphatase that regulates cell responses in lymphocytes and myeloid cells by hydrolyzing the second messenger PI(3,4,5) trisphosphate. SHIP-1 is recruited upon engagement of both inhibitory and activatory receptors, such as FcgammaRIIB, Fcgamma RIII, FcepsilonRI or cytokine and growth factor receptors, and supresses PI3K-dependent signaling, down-regulates cell migration and invasion of transformed cells and phagocytosis. SHIP-1 also serves as a scaffold for the recruitment of other proteins to the plasma membrane.
- Immunogen:
- Peptide coresponding to a sequence within N-terminal domain of human SHIP-1.
- Isotype:
- IgG2a
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- The antibody SHIP-01 reacts with SHIP-1, a phosphoinositide phosphatase largely confined to hematopoietic cells (intracellular antigen). Multiple forms of SHIP-1 have been reported with molecular weights of 110, 125, 130, 135 and 145 kDa.
- Storage Conditions:
- 2-8[o]C Do not freeze.
- Supplier:
- Exbio
- Type:
- Antibody
