Anti-SOS Purified
Product Sizes
0.025 mg
£121.00
11-522-0.025MG
0.1 mg
£202.00
11-522-0.1MG
About this Product
- SKU:
- 11-522
- Application:
- Immunocytochemistry, Western Blot
- CE/IVD:
- RUO
- translate.label.attr.clone:
- SOS-01
- Concentration:
- 1 mg/ml
- Extra Details:
- The guanine nucleotide exchange factor Sos (son-of-sevenless) is a complex multidomain protein that activates the small GTPase Ras (H-Ras, K-Ras, N-Ras, but not functionally distinct R-Ras) in response to receptor tyrosine kinase stimulation. Nucleotide exchange activity of Sos is stimulated by allosteric Ras binding. By another (separable) guanine exchange factor domain domain Sos modulates activity of Rac/Rho GTPases. Sos thus integrates signals that affect both gene expression and cytoskeletal reorganization; the Sos-mediated Ras-activation and Rac activation differ in composition and stability of the formed complex.
- Immunogen:
- Peptide corresponding to amino acids THPSMHRDGPPLLENAHSS of human Sos protein.
- Isotype:
- IgG1
- Reactivities:
- Human, Mouse, Non-human Primate
- Shipping Conditions:
- Blue Ice
- Specificity:
- The antibody SOS-01 reacts with human Sos, an ubiquitously expressed 150 kDa intracellular protein. The epitope sequence is highly conserved and reactivity with multiple species is expected.
- Storage Conditions:
- 2-8[o]C Do not freeze.
- Supplier:
- Exbio
- Type:
- Antibody
