Anti-Hu CD105 Purified
Product Sizes
0.025 mg
£116.00
11-453-0.025MG
0.1 mg
£192.00
11-453-0.1MG
About this Product
- SKU:
- 11-453
- Application:
- Flow Cytometry, IHC-Frozen, Immunocytochemistry, Western Blot
- CE/IVD:
- RUO
- translate.label.attr.clone:
- MEM-229
- Concentration:
- 1 mg/ml
- Extra Details:
- CD105 (endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.
- Immunogen:
- Recombinant Vaccinia virus containing the human CD105 (L-isoform) cDNA.
- Isotype:
- IgG2a
- Reactivities:
- Human, Porcine
- Shipping Conditions:
- Blue Ice
- Specificity:
- The antibody MEM-229 recognizes an extracellular epitope of CD105 (Endoglin), a 90 kDa type I integral membrane homodimer glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow; it is a
- Storage Conditions:
- 2-8[o]C Do not freeze.
- Supplier:
- Exbio
- Type:
- Antibody
