Anti-Neurofilament H Purified
Product Sizes
0.025 mg
£127.00
11-440-0.025MG
0.1 mg
£213.00
11-440-0.1MG
About this Product
- SKU:
- 11-440
- Application:
- ELISA, IHC-Frozen, Western Blot
- CE/IVD:
- RUO
- translate.label.attr.clone:
- NF-05
- Concentration:
- 1 mg/ml
- Extra Details:
- Neurofilaments (NFs) are a type of intermediate filament (IF) expressed almost exclusively in neuronal cells, and in those cells most prominently in large axons. NFs in most vertebrates are composed of three different polypeptide chains with different molecular weights - neurofilament heavy protein (NF-H), medium (NF-M) and light protein (NF-L), which share sequence and structural similarity in a coiled-coil core domain, but differ in the length and sequence of their N-termini and more dramatically of their C-termini which in the case of NF-M and NF-H form the flexible extensions that link NFs to each other and to other elements in the cytoplasm. The protein segment on the C-terminal side of the human NF-H rod is uniquely long (more than 600 amino acids) compared to other IF proteins and is highly charged (> 24 % Glu, > 25 % Lys), rich in proline (> 12 %) and improverished in cysteine, methionine and aromatic amino acids. Its most remarkable feature is a repetitive sequence that covers more than half its lenght and includes the sekvence motif Lys-Ser-Pro (KSP) greater than 40 times. Plasma neurofilament heavy chain level has been proposed as a marker of axonal injury and clinical use of its degeneration and loss has been suggested as a biomarker of several neurodegenerative diseases.
- Immunogen:
- Pig brain neurofilament protein-enriched fraction after depolymerization of microtubules
- Isotype:
- IgG1
- Reactivities:
- Human, Porcine, Rat
- Shipping Conditions:
- Blue Ice
- Specificity:
- The antibody NF-05 recognizes a nonphosphorylated epitope of neurofilament heavy protein (NF-H), a 210 kDa intracellular structural protein of Intermediate Filament Proteins family. NF-H is mainly expressed in the central and peripheral nervous system and reproductive system and is biochemically very stable.
- Storage Conditions:
- 2-8[o]C Do not freeze.
- Supplier:
- Exbio
- Type:
- Antibody
