Anti-LIME1 Purified
Product Sizes
0.025 mg
£138.00
11-410-0.025MG
0.1 mg
£235.00
11-410-0.1MG
About this Product
- SKU:
- 11-410
- Application:
- IHC-Paraffin, Western Blot
- CE/IVD:
- RUO
- translate.label.attr.clone:
- PAb (410)
- Concentration:
- 1 mg/ml
- Extra Details:
- LIME (Lck-interacting molecule) is a 30 kDa double-palmitoylated protein with unusually basic cytoplasmic domain, expressed by T cells. After ligation of CD4 or CD8 T cell coreceptors, LIME is phosphorylated by Src-family kinases and associates with Lck and Fyn kinases and with their negative regulator Csk. Interestingly, Csk-mediated phosphorylation of C-terminal negative-regulatory tyrosine of LIME-associated Lck can result in increase of enzymatic activity compared with the total pool of Lck, thus, LIME serves as a positive regulator of TCR-dependent T cell signaling. However, under some circumstances, LIME may mediate inhibitory signals.
- Immunogen:
- Bacterially expressed intracellular fragment corresponding to aa 141-295 of human LIME.
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- The polyclonal antibody reacts with the cytoplasmic domain of LIME, a 30 kDa Lck-interacting transmembrane adaptor expressed by T cells.
- Storage Conditions:
- 2-8[o]C Do not freeze.
- Supplier:
- Exbio
- Type:
- Antibody
