Anti-SLP76 Purified
Product Sizes
0.025 mg
£138.00
11-402-0.025MG
0.1 mg
£235.00
11-402-0.1MG
About this Product
- SKU:
- 11-402
- Application:
- IHC-Paraffin, Western Blot
- CE/IVD:
- RUO
- translate.label.attr.clone:
- SLP-76/03
- Concentration:
- 1 mg/ml
- Extra Details:
- SLP76 (SH2 domain-containing leukocyte protein of 76 kDa) is a cytosolic adaptor protein which translocates to the plasma mambrane and is involved in multiple signaling pathways in T cells, mast cells, neutrophils and platelets; B cells express its analog SLP65/BLNK (B cell linker protein). SLP76 is phosphorylated by Syk-family and Tec-family tyrosine kinases and couples them to the phosphorylation and activation of PLC-gamma. Via Gads or Grb2, SLP76 also associates with LAT adaptor by involvement of SLP76 proline-rich region. The SH2 domain of SLP76 has been identified as the region involved in binding the serine/threonine kinase HPK1. HPK1 may act as both a positive and a negative regulator by promoting the Jnk-mitogen activated protein kinase (MAPK) pathway and inhibiting the pathway leading to AP-1 activation.
- Immunogen:
- Bacterially expressed fusion protein representing amino acids 216-434 of human SLP76 with histidine tag
- Isotype:
- IgG2b
- Reactivities:
- Human, Mouse, Porcine
- Shipping Conditions:
- Blue Ice
- Specificity:
- The monoclonal antibody reacts with SLP76, a 76kDa cytosolic adaptor protein that is involved in signaling of various hematopoietic cells, such as T cells, mast cells or neutrophils; in B cells, however, it is replaced by SLP65.
- Storage Conditions:
- 2-8[o]C Do not freeze.
- Supplier:
- Exbio
- Type:
- Antibody
