Anti-DAXX Purified
Product Sizes
0.025 mg
£121.00
11-351-0.025MG
0.1 mg
£202.00
11-351-0.1MG
About this Product
- SKU:
- 11-351
- Application:
- Immunocytochemistry, Western Blot
- CE/IVD:
- RUO
- translate.label.attr.clone:
- DAXX-01
- Concentration:
- 1 mg/ml
- Extra Details:
- Daxx is an apoptosis-modulating death domain-associated protein with functions in transcriptional regulation. Daxx functions both in cytoplasm, where it interacts with Fas, and in nucleus (residing in PML oncogenic domains), where it is involved in SUMO-dependent regulation of transcription and subnuclear compartmentalization. Daxx senzitizes the cells to apoptosis, but on the other hand, this protein may also serve in preventing apoptosis in the early embryo. Even regarding the transcription, Daxx can serve both as a corepressor and a coactivator. During ischemic stress, Daxx translocates from the nucleus to the cytoplasm, where in regulates sodium hydrogen exchanger isoform 1 (NHE1).
- Immunogen:
- Recombinant C-terminal part (aa 558-740) of human Daxx.
- Isotype:
- IgG1
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- The mouse monoclonal antibody DAXX-01 recognizes Daxx, a cytoplasmic death domain containing protein mainly expressed in fetal and adult human and mouse tissue.
- Storage Conditions:
- 2-8[o]C Do not freeze.
- Supplier:
- Exbio
- Type:
- Antibody
