Anti-Hu CD170 Purified
Product Sizes
0.025 mg
£132.00
11-156-0.025MG
0.1 mg
£224.00
11-156-0.1MG
About this Product
- SKU:
- 11-156
- Application:
- ELISA, Flow Cytometry, IHC-Frozen, Immunocytochemistry, Immunoprecipitation
- CE/IVD:
- RUO
- translate.label.attr.clone:
- 1A5
- Concentration:
- 1 mg/ml
- Extra Details:
- CD170, also known as Siglec 5 (sialic acid binding Ig-like lectin 5) is a type 1 transmembrane glycoprotein containing two cytoplasmic immunoreceptor tyrosine inhibitory motifs (ITIMs). CD170 forms homodimers and functions as an inhibitory receptor able to downregulate cell activation. It binds to alpha2,3- and alpha2,6-linked sialic acid ligands, e.g. on glycophorin A (CD235a). Aberrant expression of CD170 by CD34+ progenitor cells can be observed in case of acute myeloid leukemias.
- Immunogen:
- Fusion protein composed of human CD170 extracellular domain and Fc region of human IgG1
- Isotype:
- IgG1
- Reactivities:
- Human, Non-human Primate
- Shipping Conditions:
- Blue Ice
- Specificity:
- The mouse monoclonal antibody 1A5 recognizes an extracellular epitope of CD170 (Siglec-5, sialic acid binding Ig-like lectin 5), a transmembrane glycoprotein expressed strongly by neutrophils, macrophages activated during infections, monocytes, and dendritic cells. As in case with other anti-CD170 antibodies, this antibody crossreacts with Siglec-14, whose first two Ig domains are almost identical
- Storage Conditions:
- 2-8[o]C Do not freeze.
- Supplier:
- Exbio
- Type:
- Antibody
