Anti-Hu CD172b Purified
Product Sizes
0.025 mg
£111.00
11-134-0.025MG
0.1 mg
£181.00
11-134-0.1MG
About this Product
- SKU:
- 11-134
- Application:
- Flow Cytometry
- CE/IVD:
- RUO
- translate.label.attr.clone:
- B4B6
- Concentration:
- 1 mg/ml
- Extra Details:
- CD172b, the signal-regulatory protein beta (SIRP beta) is a disulfide-linked homodimer expressed on myeloid cells including monocytes and dendritic cells. Similarly to CD172a, it serves as a negative regulator of tyrosine kinase-coupled signaling processes. Unlike CD172a, the CD172b protein does not possess the cytoplasmic domain, but instead its transmembrane domain can interact with another transmembrane protein DAP-12, which contains ITAM sequences in its intracellular domain and links CD172b to the downstream signaling molecules. The result is e.g. regulation of neutrophil transepithelial migration.
- Immunogen:
- NIH-3T3 cells transfected with human CD172b
- Isotype:
- IgG1
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- The mouse monoclonal antibody B4B6 recognizes an extracellular epitope of CD172b, an approximately 50 kDa transmembrane glycoprotein expressed on myeloid cells.
- Storage Conditions:
- 2-8[o]C Do not freeze.
- Supplier:
- Exbio
- Type:
- Antibody
