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Tau (K18) P301L Mutant Pre-formed Fibrils

Product Sizes
100 ug
£688.00
ORB1822356-100UG
About this Product
SKU:
ORB1822356
Application:
In Vivo Administration, SDS-PAGE, Western Blot
Buffer:
10 mM HEPES; 100 mM NaCl pH 7.4
Concentration:
2 mg/ml
Purity:
>95%
Reactivities:
Human
Sequence:
SRLQTAPVPM PDLKNVKSKI GSTENLKHQP GGGKVQIINK KLDLSNVQSK CGSKDNIKHVLGGGSVQIVY KPVDLSKVTS KCGSLGNIHH KPGGGQVEVK SEKLDFKDRV QSKIGSLDNI THVPGGGNKK IETHKLTFRE
Shipping Conditions:
Dry Ice
Source:
Recombinant
Storage Conditions:
-80°C
Supplier:
Biorbyt
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules
TEM of recombinant Tau (K18); P301L mutant Pre-formed Fibrils (PFFs) at 150kx magnification. HV=80kV.
TEM of recombinant Tau (K18); P301L mutant Pre-formed Fibrils (PFFs) at 150kx magnification. HV=80kV.
Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures; such as those in tau fibrils. Upon binding; the emission spectrum of the dye experiences a red-shift and increased fluorescence intensity. Thioflavin T emission curves show increased fluorescence (correlated to tau aggregation) over time in tau Pre-formed Fibrils. Tau Pre-formed Fibrils seed the formation of new tau fibrils when combined with tau monomers. Thioflavin T ex = 450 nm; em = 485 nm. 10 uM heparin was added to each well.
SDS-PAGE of ~15 kDa Active Human Tau Protein K18 P301L Pre-formed Fibrils. Lane 1: MW Ladder. Lane 2: Tau Protein Pre-formed Fibrils.