Anti-TBP
Product Sizes
25ul
£177.00
P100971-T100-25UL
100 ul
£373.00
P100971-T100-100UL
About this Product
- SKU:
- P100971-T100
- Additional Names:
- HDL4; GTF2D; SCA17; TFIID; GTF2D1
- Clonality:
- Polyclonal
- Concentration:
- 1.0 mg/ml
- Extra Details:
- Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID); which binds to the core promoter to position the polymerase properly; serves as the scaffold for assembly of the remainder of the transcription complex; and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription; serve as coactivators; function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP; the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminal. This region of the protein modulates the DNA binding activity of the C terminus; and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. Mutations that expand the number of CAG repeats encoding this polyglutamine tract; and thus increase the length of the polyglutamine string; are associated with spinocerebellar ataxia 17; a neurodegenerative disorder classified as a polyglutamine disease.
- Gene Details:
- TATA box binding protein
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the middle region of human TBP
- Molecular Weight:
- 38kDa
- Protein Details:
- TATA-box-binding protein
- Purification:
- Protein A purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
