Aviva Systems Biology
Offering antibodies to more than 7000 different targets, many that are implicated in transcription, epigenetics and cell signalling, Aviva Systems Biology leverages a high throughput antibody production process to release over 200 new antibody products every month. These complement a portfolio that already covers most members of key protein families - including transcription factors, transcription regulators, RNA binding proteins, ion channels and cell membrane proteins – underscoring Aviva’s reputation as a leader of novel proteomic discoveries.
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Aviva Systems Biology Honored with Bioz Rapid Star™ Award in Antibodies Category!
Aviva Systems Biology is proud to announce that it has been selected as the 2024 Bioz Stars Award Winner in the Antibodies category. This recognition highlights Aviva's significant growth and impact in the scientific community, as evidenced by the increasing number of citations of its antibody products in peer-reviewed research publications.
"We’re honoured to receive the Bioz Rapid Star Award," said Dr. Nicole Hoffner, Product Manager at Aviva Systems Biology. "This award isn’t just a reflection of the quality of our 80,000+ antibodies, it’s a testament to the hard work and ground-breaking research of our customers. We’re proud to support the scientific community with tools they can trust, and we’re just getting started. Our R&D team is actively developing new recombinant antibodies designed to push performance even further. Stay tuned."
Recombinant antibodies engineered for consistency, delivering reproducible performance in diagnostic, therapeutic and molecular image applications
The recent surge in use of recombinant DNA technology has afforded the life science market essential advantages over non-recombinant antibody types. The technology allows consistent identification of specific antibody sequences and allows the sequences to be cloned and expressed easily and precisely.
Here are some key advantages that Aviva’s recombinant range can offer researchers:
High specificity: Recombinant antibodies are engineered to have very high specificity and selectivity for their target antigen.
Reduced batch variability and improved reproducibility: Recombinant antibodies are produced in a controlled and standardised manner, ensuring batch-to-batch consistency.
Availability for difficult targets: In cases where traditional immunisation methods fail to generate antibodies against highly conserved or difficult-to-obtain antigens, recombinant antibody generation allows access to antibodies that specifically recognise challenging antigens.
Scalability and renewable supply: Recombinant antibodies can be produced in large quantities more easily than traditional antibody production methods. This innovative platform allows for the sustainable and continuous production of the same antibodies.
Discover a selection of products for specific targets below:
Protein on Demand
Protein tags have become indispensable in recombinant protein research, offering solutions to the persistent challenges of producing proteins in systems where they are not naturally expressed. Many recombinant proteins are difficult to isolate in sufficient quantity or purity, and they may misfold, aggregate, or degrade without additional support. By attaching short peptide or protein sequences, typically at the N- or C-terminus of a protein, researchers can simplify detection, streamline purification, and enhance solubility and stability. But not all tags are created equal. Because the choice of tag can significantly influence experimental outcomes, understanding the strengths and limitations of different tagging strategies is vital to selecting the one best suited for your specific application.
Common Functions of Protein Tags
Researchers can leverage different protein tags to accomplish a wide spectrum of functions. Broadly, tags fall into the following functional categories:
- Purification
- Detection
- Solubility/Folding Enhancement
- Stability/Half-Life Extension
While some tags, such as MBP or GST, can serve multiple functions, their suitability for a particular application is dependent on the protein of interest, as well as other experimental conditions and goals.
How to Choose the Right Tag
With countless protein tags available, selecting the right one can feel overwhelming, especially if you’re new to a specific technique. When choosing a protein tag, here are some important factors[v] to consider:
- Downstream application
- Size of the tag
- Ease of removal
- Expression system compatibility
- Detection requirements
