Skip to content

Basket

You currently have no items in your basket.

Total (excl. vat) £0.00
View basket & checkout

IL31 Protein

Product Sizes
2µg
£186.00
OPPA02472-2UG
About this Product
SKU:
OPPA02472
Additional Names:
1700013B14Rik
Concentration:
1 mg/ml (prior to lyophilization)
Extra Details:
IL-31 produced by activated Th2-type T cells; cooperates with a heterodimeric receptor consisting of IL-31 Receptor Anatagonist and Onconstatin-M Receptor that is continuesly expressed on epithelial cells and keratinocytes. IL-31 plays a role in the promotion of allergic skin disorders and in regulating other allergic diseases; such as asthma. IL-31 is involved in the itching sensation and endorses the scratching behavior in NC/Nga mice with atopic dermatitis. IL-31 expression is connectd with CLA(+) T cells and contributes to the development of atopic dermatitis-induced skin inflammation and pruritus. IL-31 is a powerful inducer of proinflammatory mediators in human colonic SEMFs. IL-31 takes part as a proinflammatory cytokine derived from Th2 cells. Serum IL-31 level is higher in patients with atopic dermatitis. IL-31 is involved in a broad range of immune- & non-immune cells & possesses potential pleiotropic physiological functions; including regulating hematopoiesis & immune responses. IL31 mouse recombinant produced in E.Coli is a single; non-glycosylated; polypeptide chain containing 141 amino acids.
Host:
E. coli
Molecular Weight:
16 kDa
Protein Details:
Interleukin-31
Purity:
Greater than 95.0% (SDS-PAGE)
Shipping Conditions:
Ambient
Storage Conditions:
It is recommended to reconstitute the lyophilized IL31 in sterile 18M-omega-cm H2O not less than 100 ug/mL; which can then be further diluted to other aqueous solutions. Lyophilized IL31 Recombinant; although stable at room temperature for 3 weeks; should be stored desiccated below -18C. Upon reconstitution; IL31 should be stored at 4C between 2-7 days and for future use below -18C. Please prevent freeze-thaw cycles.
Supplier:
Aviva Systems Biology
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules