CALR Protein
Product Sizes
5µg
£186.00
OPPA02268-5UG
About this Product
- SKU:
- OPPA02268
- Additional Names:
- RO; CRT; SSA; cC1qR; HEL-S-99n
- Concentration:
- 1 mg/ml
- Extra Details:
- CALR is a multifunctional protein that acts as a main Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. Calreticulin is localized in the nucleus; and participates in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR; which is nearly identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. CALR binds to antibodies in specific sera of systemic lupus and Sjogren patients which have anti-Ro/SSA antibodies; it is well conserved among species; and it is positioned in the endoplasmic and sarcoplasmic reticulum where it binds calcium. The amino terminus of CALR interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. CALR reduces the binding of androgen receptor to its hormone-responsive DNA element and inhibits androgen receptor and retinoic acid receptor transcriptional activities in vivo; as well as retinoic acid-induced neuronal differentiation. Therefore; CALR acts as a significant modulator of the regulation of gene transcription by nuclear hormone receptors.
- Host:
- E. coli
- Molecular Weight:
- 49 kDa
- Protein Details:
- Calreticulin
- Purity:
- Greater than 85% as determined by SDS-PAGE.
- Purification:
- Purified by standard chromatography
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4°C if entire vial will be used within 2-4 weeks. Store frozen at -20°C for longer periods of time. For long term storage; it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze/thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:html_datasheet.php
