B2M Human - Human Beta 2 Microglobulin Protein
Product Sizes
200µg
£229.00
OPPA01430-200UG
About this Product
- SKU:
- OPPA01430
- Additional Names:
- IMD43
- Extra Details:
- Beta 2 microglobulin is an 11 kDa protein associated with the outer membrane of many cells including lymphocytes. It is the small subunit of the MHC class I molecule. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2 microglobulin associates with class I-like molecules such as CD1 and Qa as well as with the alpha chain of MHC class I molecules. Very limited amounts of MHC class I molecules can be found on the surface in the absence of Beta 2 microglobulin. CD8 T cells cannot develop in the absence of MHC class I. Beta 2-microglobulin is present in small amounts in serum; csf; and urine of normal people; and to a much greater degree in the urine and plasma of patients with tubular proteinaemia; renal failure; or kidney transplants. Human Beta 2 microglobulin levels can rise either because its rate of synthesis has increased (e.g. in AIDS; malignant monoclonal plasma cell dyscrasia; solid tumors and autoimmune disease) or because of impaired renal filtration (e.g. due to renal insufficiency; graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy). Beta-2 microglobulin levels might also be elevated in multiple myeloma and lymphoma cases. Dialysis-related amyloidosis develops after a long-term hemodialysis; it can aggregate into amyloid fibers that deposit in joint spaces
- Host:
- Human
- Molecular Weight:
- 12 kDa
- Protein Details:
- Beta-2-microglobulin
- Purity:
- Greater than 98.0% as determined by SDS-PAGE.
- Shipping Conditions:
- Ambient
- Source:
- Human urine from patients with tubular proteinuria
- Storage Conditions:
- It is recommended to reconstitute the lyophilized B2M in phosphate buffer pH > 7.0 containing 0.15M NaCl. Human B2M although stable at room temperature for 3 weeks; should be stored between 2-8°C.
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:html_datasheet.php
