S100B Protein
Product Sizes
5µg
£186.00
OPPA01222-5UG
About this Product
- SKU:
- OPPA01222
- Additional Names:
- NEF; S100; S100-B; S100beta
- Concentration:
- 1 mg/ml
- Extra Details:
- S100B Human Recombinant produced in E.Coli is single; a non-glycosylated; Polypeptide chain containing 112 amino acids fragment (1-92) with a 20 amino acid. S100b is a member of the S100 family of proteins which are a family of EF-hand calcium binding proteins that exist mostly as dimers of the 20 currently identified individual S100 monomers. The S100B homodimer is expressed in cells of the central nervous system; glial cells and in certain peripheral cells e.g. Schwann cells; melanocytes; adipocytes and chondrocytes. S100 proteins are localized either in the cytoplasm or the nucleus of a wide range of cells. S100 proteins are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. There are at least 13 members in the S100 gene family; which are located as a cluster on chromosome 1q21; however; S100b is located at 21q22.3. The determination of S100B in serum levels may be used to monitor the extent of brain injury and malignant melanoma. S100b proteins may have a role in Neurite extension; proliferation of melanoma cells; stimulation of Ca2+ fluxes; inhibition of PKC-mediated phosphorylation; astrocytosis and axonal proliferation; and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of the S100b gene are implicated in several neurological; neoplastic; and other types of diseases; including Alzheimer's disease; Down's syndrome; epilepsy; amyotrophic lateral sclerosis; melanoma; and type I diabetes.
- Host:
- E. coli
- Molecular Weight:
- 13 kDa
- Protein Details:
- Protein S100-B
- Purity:
- Greater than 90.0% as determined by SDS-PAGE.
- Purification:
- Purified by proprietary chromatographic techniques.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4C if entire vial will be used within 2-4 weeks. Store; frozen at -20C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:html_datasheet.php
