CD40LG Recombinant Protein
Product Sizes
10 ug
£912.00
OPED00085-10UG
About this Product
- SKU:
- OPED00085
- Additional Names:
- 30 kDa adipocyte complement-related protein;30kDa;a;Acd;Acdc;Acr;Acrp30;Ad;Adid;adip;adipo;adipocyte complement related protein;adipocyte complement-related 30 kDa protein;adipocyte; C1Q and collagen domain containing;adipocyte; C1q and collagen domain-containing protein;adipocyte-specific protein AdipoQ;adiponectin;adiponectin d;ap;apM1;APN;CD154;CD40 antigen ligand;CD40 ligand;CD40L;CD40-L;GBP2;GBP28;gp39;hCD40L;HIGM1;IGM;IMD3;T-B cell-activating molecule;T-BAM;T-cell antigen Gp39;TNF-related activation protein;TNFSF5;TRAP;tumor necrosis factor (ligand) superfamily member 5;Tumor necrosis factor ligand superfamily member 5.
- Extra Details:
- Cytokine that binds to CD40/TNFRSF5 (PubMed:1280226). Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching (By similarity).|Important adipokine involved in the control of fat metabolism and insulin sensitivity; with direct anti-diabetic; anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle; enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages; and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth; angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities; depending on the type of complex; LMW; MMW or HMW.
- Gene Details:
- adiponectin; C1Q and collagen domain containing|CD40 ligand
- Molecular Weight:
- 38 kDa
- Protein Details:
- Adiponectin|CD40 ligand
- Purity:
- >90% (SDS-PAGE)
- Purification:
- Purified by multi-step chromatography.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Reconstitute with 100 ul sterile water. Further dilutions should be made with medium containing 5% fetal calf serum. Store at -20C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
