TRAF6 Recombinant Protein
Product Sizes
10ug
£272.00
OPCD07701-10UG
50ug
£528.00
OPCD07701-50UG
200ug
£955.00
OPCD07701-200UG
About this Product
- SKU:
- OPCD07701
- Additional Names:
- 2310003F17Rik;AI851288;C630032O20Rik;E3 ubiquitin-protein ligase TRAF6;RING-type E3 ubiquitin transferase TRAF6;TNF receptor-associated factor 6.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- E3 ubiquitin ligase that; together with UBE2N and UBE2V1; mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins; such as IKBKG; IRAK1; AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation (By similarity). Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation; in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor; IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B; in response to RANK-L stimulation. Together with MAP3K8; mediates CD40 signals that activate ERK in B-cells and macrophages; and thus may play a role in the regulation of immunoglobulin production.
- Gene Details:
- TNF receptor-associated factor 6
- Host:
- E. coli
- Molecular Weight:
- 34kDa
- Protein Details:
- TNF receptor-associated factor 6
- Purity:
- > 95%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
