TNFRSF21 Recombinant Protein
Product Sizes
10ug
£268.00
OPCD07574-10UG
50ug
£522.00
OPCD07574-50UG
200ug
£940.00
OPCD07574-200UG
About this Product
- SKU:
- OPCD07574
- Additional Names:
- BM-018;CD358;death receptor 6;DR6;TNFR-related death receptor 6;tumor necrosis factor receptor superfamily member 21.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Promotes apoptosis; possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis; including apoptosis in response to amyloid peptides derived from APP; and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival; maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors; in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4; IL5; IL10; IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG; IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation.
- Gene Details:
- TNF receptor superfamily member 21
- Host:
- E. coli
- Molecular Weight:
- 19kDa
- Protein Details:
- Tumor necrosis factor receptor superfamily member 21
- Purity:
- > 95%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
