TLR6 Recombinant Protein
Product Sizes
10ug
£268.00
OPCD07506-10UG
50ug
£522.00
OPCD07506-50UG
200ug
£940.00
OPCD07506-200UG
About this Product
- SKU:
- OPCD07506
- Additional Names:
- CD286;toll-like receptor 6.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and; to a lesser extent; triacylated lipopeptides (PubMed:20037584). In response to diacylated lipopeptides; forms the activation cluster TLR2:TLR6:CD14:CD36; this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6; leading to NF-kappa-B activation; cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2); soluble tuberculosis factor (STF); phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2 (PubMed:11441107). In complex with TLR4; promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context; the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6; which is rapidly internalized and triggers inflammatory response; leading to the NF-kappa-B-dependent production of CXCL1; CXCL2 and CCL9 cytokines; via MYD88 signaling pathway; and CCL5 cytokine; via TICAM1 signaling pathway; as well as IL1B secretion (PubMed:11441107; PubMed:20037584).
- Gene Details:
- toll like receptor 6
- Host:
- E. coli
- Molecular Weight:
- 26kDa
- Protein Details:
- Toll-like receptor 6
- Purity:
- > 95%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
