TLR4 Recombinant Protein
Product Sizes
10ug
£240.00
OPCD07500-10UG
50ug
£446.00
OPCD07500-50UG
200ug
£788.00
OPCD07500-200UG
About this Product
- SKU:
- OPCD07500
- Additional Names:
- ARMD10;CD284;homolog of Drosophila toll;hToll;TLR-4;TOLL;toll like receptor 4 protein;toll-like receptor 4.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:27022195). Acts via MYD88; TIRAP and TRAF6; leading to NF-kappa-B activation; cytokine secretion and the inflammatory response (PubMed:9237759; PubMed:10835634; PubMed:27022195). Also involved in LPS-independent inflammatory responses triggered by free fatty acids; such as palmitate; and Ni(2+). Responses triggered by Ni(2+) require non-conserved histidines and are; therefore; species-specific (PubMed:20711192). Both M.tuberculosis HSP70 (dnaK) and HSP65 (groEL-2) act via this protein to stimulate NF-kappa-B expression (PubMed:15809303). In complex with TLR6; promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context; the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6; which is rapidly internalized and triggers inflammatory response; leading to the NF-kappa-B-dependent production of CXCL1; CXCL2 and CCL9 cytokines; via MYD88 signaling pathway; and CCL5 cytokine; via TICAM1 signaling pathway; as well as IL1B secretion. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187). Stimulation of monocytes in vitro with M.tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via TLR2; but also partially via this receptor (PubMed:16622205).
- Gene Details:
- toll like receptor 4
- Host:
- E. coli
- Molecular Weight:
- 40kDa
- Protein Details:
- Toll-like receptor 4
- Purity:
- > 95%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
