TLR4 Recombinant Protein
Product Sizes
10ug
£235.00
OPCD07498-10UG
50ug
£435.00
OPCD07498-50UG
200ug
£766.00
OPCD07498-200UG
About this Product
- SKU:
- OPCD07498
- Additional Names:
- lipopolysaccharide response;Lps;Ly87;Ran/M1;Ras;Rasl2-8;Toll like receptor 4;toll-like receptor 4.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:9851930; PubMed:9989976; PubMed:20133493). Acts via MYD88; TIRAP and TRAF6; leading to NF-kappa-B activation; cytokine secretion and the inflammatory response (PubMed:24380872). Also involved in LPS-independent inflammatory responses triggered by free fatty acids; such as palmitate. In complex with TLR6; promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context; the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6; which is rapidly internalized and triggers inflammatory response; leading to the NF-kappa-B-dependent production of CXCL1; CXCL2 and CCL9 cytokines; via MYD88 signaling pathway; and CCL5 cytokine; via TICAM1 signaling pathway; as well as IL1B secretion. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (By similarity).
- Gene Details:
- toll-like receptor 4
- Host:
- E. coli
- Molecular Weight:
- 38kDa
- Protein Details:
- Toll-like receptor 4
- Purity:
- > 95%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
