SSRP1 Recombinant Protein
Product Sizes
10ug
£279.00
OPCD07200-10UG
50ug
£550.00
OPCD07200-50UG
200ug
£994.00
OPCD07200-200UG
About this Product
- SKU:
- OPCD07200
- Additional Names:
- chromatin-specific transcription elongation factor 80 kDa subunit;cisplatin-DNA SSRP;facilitates chromatin remodeling 80 kDa subunit;facilitates chromatin transcription complex 80 kDa subunit;facilitates chromatin transcription complex subunit SSRP1;FACT;FACT 80 kDa subunit;FACT complex subunit SSRP1;FACT80;FACTp80;high mobility group box;hSSRP1;recombination signal sequence recognition protein 1;Structure-specific recognition protein 1;T160.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Component of the FACT complex; a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation; DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome; then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63.
- Gene Details:
- structure specific recognition protein 1
- Host:
- E. coli
- Molecular Weight:
- 33kDa
- Protein Details:
- FACT complex subunit SSRP1
- Purity:
- > 95%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
