SOCS3 Recombinant Protein
Product Sizes
10ug
£257.00
OPCD07099-10UG
50ug
£496.00
OPCD07099-50UG
200ug
£890.00
OPCD07099-200UG
About this Product
- SKU:
- OPCD07099
- Additional Names:
- ATOD4;CIS3;Cish3;cytokine-inducible SH2 protein 3;SOCS-3;SSI3;SSI-3;STAT-induced STAT inhibitor 3;suppressor of cytokine signaling 3.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130; LIF; erythropoietin; insulin; IL12; GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity).
- Gene Details:
- suppressor of cytokine signaling 3
- Host:
- E. coli
- Molecular Weight:
- 31kDa
- Protein Details:
- Suppressor of cytokine signaling 3
- Purity:
- > 90%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
