SIRT6 Recombinant Protein
Product Sizes
10ug
£240.00
OPCD07012-10UG
50ug
£446.00
OPCD07012-50UG
200ug
£788.00
OPCD07012-200UG
About this Product
- SKU:
- OPCD07012
- Additional Names:
- 2810449N18Rik;AI043036;NAD-dependent deacetylase sirtuin-6;NAD-dependent protein deacetylase sirtuin-6;regulatory protein SIR2 homolog 6;Sir2l6;SIR2-like protein 6.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. On DNA damage; promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate (By similarity). Acts as a corepressor of the transcription factor Hif1a to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. Regulates the production of TNF protein. Has a role in the regulation of life span in male mice; but not in female mice.
- Gene Details:
- sirtuin 6
- Host:
- E. coli
- Molecular Weight:
- 38kDa
- Protein Details:
- NAD-dependent protein deacetylase sirtuin-6
- Purity:
- > 95%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
