SIGLEC10 Recombinant Protein
Product Sizes
10ug
£261.00
OPCD06973-10UG
50ug
£500.00
OPCD06973-50UG
200ug
£901.00
OPCD06973-200UG
About this Product
- SKU:
- OPCD06973
- Additional Names:
- PRO940;sialic acid binding Ig-like lectin 10 Ig-like lectin 7;sialic acid-binding Ig-like lectin 10;SIGLEC-10;siglec-like gene 2;siglec-like protein 2;SLG2.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2;3- or alpha-2;6-linked sialic acid (By similarity). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response; seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules (PubMed:11284738; PubMed:12163025). Involved in negative regulation of B-cell antigen receptor signaling. The inhibition of B cell activation is dependent on PTPN6/SHP-1 (By similarity). In association with CD24 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1; HSP70 and HSP90 (By similarity). In association with CD24 may regulate the immune repsonse of natural killer (NK) cells (PubMed:25450598). Plays a role in the control of autoimmunity (By similarity). During initiation of adaptive immune responses by CD8-alpha(+) dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. The function seems to implicate recruitment of PTPN6/SHP-1; which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification (By similarity).
- Gene Details:
- sialic acid binding Ig like lectin 10
- Host:
- E. coli
- Molecular Weight:
- 17kDa
- Protein Details:
- Sialic acid-binding Ig-like lectin 10
- Purity:
- > 95%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
