KIT Recombinant Protein
Product Sizes
10ug
£257.00
OPCD06840-10UG
50ug
£496.00
OPCD06840-50UG
200ug
£890.00
OPCD06840-200UG
About this Product
- SKU:
- OPCD06840
- Additional Names:
- CD117;C-Kit;c-Kit protooncogene;mast/stem cell growth factor receptor Kit;MASTC;p145 c-kit;PBT;piebald trait protein;proto-oncogene c-Kit;proto-oncogene tyrosine-protein kinase Kit;SCFR;soluble KIT variant 1;tyrosine-protein kinase Kit;v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog;v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation; hematopoiesis; stem cell maintenance; gametogenesis; mast cell development; migration and function; and in melanogenesis. In response to KITLG/SCF binding; KIT can activate several signaling pathways. Phosphorylates PIK3R1; PLCG1; SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1; the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS; RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1; STAT3; STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1;4;5-trisphosphate. KIT signaling is modulated by protein phosphatases; and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU; and of the transcription factors STAT1; STAT3; STAT5A and STAT5B. Promotes phosphorylation of PIK3R1; CBL; CRK (isoform Crk-II); LYN; MAPK1/ERK2 and/or MAPK3/ERK1; PLCG1; SRC and SHC1.
- Gene Details:
- KIT proto-oncogene; receptor tyrosine kinase
- Host:
- E. coli
- Molecular Weight:
- 27kDa
- Protein Details:
- Mast/stem cell growth factor receptor Kit
- Purity:
- > 90%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
