DDX58 Recombinant Protein
Product Sizes
10ug
£268.00
OPCD06694-10UG
50ug
£522.00
OPCD06694-50UG
200ug
£940.00
OPCD06694-200UG
About this Product
- SKU:
- OPCD06694
- Additional Names:
- antiviral innate immune response receptor RIG-I;DEAD (Asp-Glu-Ala-Asp) box polypeptide 58;DEAD box protein 58;DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide;probable ATP-dependent RNA helicase DDX58;retinoic acid-inducible gene 1 protein;retinoic acid-inducible gene I protein;RIG1;RIGI;RIG-I;RIG-I-like receptor 1;RLR-1;RNA helicase RIG-I;SGMRT2.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include: 5'-triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5'-triphosphate moiety; blunt-end base pairing at the 5'-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity. A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity. Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes; including interferons (IFNs); IFN-alpha and IFN-beta. Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae: Human respiratory syncytial virus and measles virus (MeV); Rhabdoviridae: vesicular stomatitis virus (VSV); Orthomyxoviridae: influenza A and B virus; Flaviviridae: Japanese encephalitis virus (JEV); hepatitis C virus (HCV); dengue virus (DENV) and west Nile virus (WNV). It also detects rotavirus and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome such as Epstein-Barr virus (EBV). Detects dsRNA produced from non-self dsDNA by RNA polymerase III; such as Epstein-Barr virus-encoded RNAs (EBERs). May play important roles in granulocyte production and differentiation; bacterial phagocytosis and in the regulation of cell migration.
- Gene Details:
- DExD/H-box helicase 58
- Host:
- E. coli
- Molecular Weight:
- 30kDa
- Protein Details:
- Probable ATP-dependent RNA helicase DDX58
- Purity:
- > 97%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
