PTEN Recombinant Protein
Product Sizes
10ug
£251.00
OPCD06472-10UG
50ug
£485.00
OPCD06472-50UG
200ug
£864.00
OPCD06472-200UG
About this Product
- SKU:
- OPCD06472
- Additional Names:
- 10q23del;BZS;CWS1;DEC;GLM2;MHAM;mitochondrial phosphatase and tensin protein alpha;mitochondrial PTENalpha;MMAC1;MMAC1 phosphatase and tensin homolog deleted on chromosome 10;mutated in multiple advanced cancers 1;Phosphatase and tensin homolog;phosphatase and tensin-like protein;phosphatidylinositol 3;4;5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN;phosphatidylinositol-3;4;5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN;protein tyrosine phosphatase;PTEN variant PTEN-K267Rfs*9;PTEN variant PTEN-L247*;PTEN variant PTEN-R234Afs*11;PTEN1;PTENbeta;PTENepsilon;TEP1.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Tumor suppressor. Acts as a dual-specificity protein phosphatase; dephosphorylating tyrosine-; serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase; removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3;4;5-trisphosphate; phosphatidylinositol 3;4-diphosphate; phosphatidylinositol 3-phosphate and inositol 1;3;4;5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3;4;5)P3 > PtdIns(3;4)P2 > PtdIns3P > Ins(1;3;4;5)P4 (PubMed:26504226). The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis; including correct neuron positioning; dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential; whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. In motile cells; suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement.
- Gene Details:
- phosphatase and tensin homolog
- Host:
- E. coli
- Molecular Weight:
- 55kDa
- Protein Details:
- Phosphatidylinositol 3;4;5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- Purity:
- > 95%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
