PPIF Recombinant Protein
Product Sizes
10ug
£268.00
OPCD06349-10UG
50ug
£511.00
OPCD06349-50UG
200ug
£918.00
OPCD06349-200UG
About this Product
- SKU:
- OPCD06349
- Additional Names:
- cyclophilin 3;cyclophilin D;cyclophilin F;CYP3;CypD;Cyp-D;CyP-M;mitochondrial cyclophilin;peptidyl-prolyl cis-trans isomerase F; mitochondrial;peptidyl-prolyl cis-trans isomerase; mitochondrial;PPIase F;rotamase F.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.
- Gene Details:
- peptidylprolyl isomerase F
- Host:
- E. coli
- Molecular Weight:
- 20.12kDa
- Protein Details:
- Peptidyl-prolyl cis-trans isomerase F; mitochondrial
- Purity:
- > 95%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
