NME4 Recombinant Protein
Product Sizes
10ug
£279.00
OPCD05688-10UG
50ug
£550.00
OPCD05688-50UG
200ug
£998.00
OPCD05688-200UG
About this Product
- SKU:
- OPCD05688
- Additional Names:
- 2610027N22Rik;2810024O08Rik;5730493H09Rik;expressed in non-metastatic cells 4; protein;NDK;NDP kinase; mitochondrial;NDPKD;NM23-M;Nm23M4;NM23-M4;non-metastatic cells 4; protein expressed in;nucleoside diphosphate kinase D;nucleoside diphosphate kinase; mitochondrial.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism; using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis. Binds to anionic phospholipids; predominantly to cardiolipin; the binding inhibits its phosphotransfer activity. Acts as mitochondria-specific NDK; its association with cardiolipin-containing mitochondrial inner membrane is coupled to respiration suggesting that ADP locally regenerated in the mitochondrion innermembrane space by its activity is directly taken up via ANT ADP/ATP translocase into the matrix space to stimulate respiratory ATP regeneration. Proposed to increase GTP-loading on dynamin-related GTPase OPA1 in mitochondria. In vitro can induce liposome cross-linking suggesting that it can cross-link inner and outer membranes to form contact sites; and promotes intermembrane migration of anionic phosphoplipids. Promotes the redistribution of cardiolipin between the mitochondrial inner membrane and outer membrane which is implicated in pro-apoptotic signaling (By similarity).
- Gene Details:
- NME/NM23 nucleoside diphosphate kinase 4
- Host:
- E. coli
- Molecular Weight:
- 18kDa
- Protein Details:
- Nucleoside diphosphate kinase; mitochondrial
- Purity:
- > 95%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
