LEPR Recombinant Protein
Product Sizes
10ug
£251.00
OPCD04917-10UG
50ug
£485.00
OPCD04917-50UG
200ug
£864.00
OPCD04917-200UG
About this Product
- SKU:
- OPCD04917
- Additional Names:
- B219;db;diabetes;LE;LEP-R;Leprb;LEPROT;leptin receptor;leptin receptor gene-related protein;Modb;Modb1;O;OB-;OB receptor;obese-;obese-like;obl;Obr;OB-RGRP.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Receptor for hormone LEP/leptin (Probable) (PubMed:11861497). On ligand binding; mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS (PubMed:10799542; PubMed:25383904; PubMed:11923481; PubMed:11861497). In the hypothalamus; LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides; also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (PubMed:10660043; PubMed:12594516). In the periphery; increases basal metabolism; influences reproductive function; regulates pancreatic beta-cell function and insulin secretion; is pro-angiogenic and affects innate and adaptive immunity (PubMed:25383904; PubMed:11923481). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling; whereas distinct signals regulate NPY and the control of fertility; growth and glucose homeostasis (PubMed:12594516). Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus (PubMed:25383904). Has a specific effect on T lymphocyte responses; differentially regulating the proliferation of naive and memory T-cells. Leptin increases Th1 and suppresses Th2 cytokine production (PubMed:9732873).
- Gene Details:
- leptin receptor
- Host:
- E. coli
- Molecular Weight:
- 24kDa
- Protein Details:
- Leptin receptor
- Purity:
- > 95%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
