LAMP2 Recombinant Protein
Product Sizes
10ug
£261.00
OPCD04837-10UG
50ug
£500.00
OPCD04837-50UG
200ug
£901.00
OPCD04837-200UG
About this Product
- SKU:
- OPCD04837
- Additional Names:
- CD107 antigen-like family member B;CD107b;DND;LAMP-2;LAMPB;LGP110;LGP-96;lysosome-associated membrane glycoprotein 2.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Plays an important role in chaperone-mediated autophagy; a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live (PubMed:8662539; PubMed:11082038; PubMed:18644871; PubMed:24880125; PubMed:27628032). Functions by binding target proteins; such as GAPDH and MLLT11; and targeting them for lysosomal degradation (PubMed:8662539; PubMed:11082038; PubMed:18644871; PubMed:24880125). Plays a role in lysosomal protein degradation in response to starvation (By similarity). Required for the fusion of autophagosomes with lysosomes during autophagy (PubMed:27628032). Cells that lack LAMP2 express normal levels of VAMP8; but fail to accumulate STX17 on autophagosomes; which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032). Required for normal degradation of the contents of autophagosomes (PubMed:27628032). Required for efficient MHCII-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHCII subunits (PubMed:20518820). Is not required for efficient MHCII-mediated presentation of endogenous antigens (PubMed:20518820).
- Gene Details:
- lysosomal associated membrane protein 2
- Host:
- E. coli
- Molecular Weight:
- 50kDa
- Protein Details:
- Lysosome-associated membrane glycoprotein 2
- Purity:
- > 95%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
