KHDRBS1 Recombinant Protein
Product Sizes
10ug
£272.00
OPCD04654-10UG
50ug
£528.00
OPCD04654-50UG
200ug
£951.00
OPCD04654-200UG
About this Product
- SKU:
- OPCD04654
- Additional Names:
- GAP-associated tyrosine phosphoprotein p62;GAP-associated tyrosine phosphoprotein p62 (Sam68);KH domain containing; RNA binding; signal transduction associated 1;KH domain-containing; RNA-binding; signal transduction-associated protein 1;p21 Ras GTPase-activating protein-associated p62;p62;p68;Sam68;src-associated in mitosis 68 kDa protein.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Recruited and tyrosine phosphorylated by several receptor systems; for example the T-cell; leptin and insulin receptors. Once phosphorylated; functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors; is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner (By similarity). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S); and of SMN1 (PubMed:17371836; PubMed:20186123). Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity).
- Gene Details:
- KH RNA binding domain containing; signal transduction associated 1
- Host:
- E. coli
- Molecular Weight:
- 36kDa
- Protein Details:
- KH domain-containing; RNA-binding; signal transduction-associated protein 1
- Purity:
- > 90%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
