IL27 Recombinant Protein
Product Sizes
10ug
£290.00
OPCD04394-10UG
50ug
£565.00
OPCD04394-50UG
200ug
£1031.00
OPCD04394-200UG
About this Product
- SKU:
- OPCD04394
- Additional Names:
- Il;IL-;IL-27;IL-27 p28 subunit;IL-27 subunit alpha;IL27-A;IL-27-A;IL-27p28;Il30;interleukin 30;interleukin-27 subunit alpha;p2;p28.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Associates with EBI3 to form the IL-27 interleukin; a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties; that can regulate T-helper cell development; suppress T-cell proliferation; stimulate cytotoxic T-cell activity; induce isotype switching in B-cells; and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1); type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells; binds to the cytokine receptor WSX-1/TCCR which appears to be required but not sufficient for IL-27-mediated signal transduction. IL-27 potentiate the early phase of TH1 response and suppress TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via two distinct pathways; p38 MAPK/TBX21- and ICAM1/ITGAL/ERK-dependent pathways. It also induces STAT1; STAT3; STAT4 and STAT5 phosphorylation and activates TBX21/T-Bet via STAT1 with resulting IL12RB2 up-regulation; an event crucial to TH1 cell commitment. It suppresses the expression of GATA3; the inhibitor TH1 cells development. In CD8 T-cells; it activates STATs as well as GZMB. IL-27 reveals to be a potent inhibitor of TH17 cell development and of IL-17 production. Indeed IL27 alone is also able to inhibit the production of IL17 by CD4 and CD8 T-cells. While IL-27 suppressed the development of proinflammatory Th17 cells via STAT1; it inhibits the development of anti-inflammatory inducible regulatory T-cells; iTreg; independently of STAT1. IL-27 has also an effect on cytokine production; it suppresses proinflammatory cytokine production such as IL2; IL4; IL5 and IL6 and activates suppressors of cytokine signaling such as SOCS1 and SOCS3. Apart from suppression of cytokine production; IL-27 also antagonizes the effects of some cytokines such as IL6 through direct effects on T-cells. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9.
- Gene Details:
- interleukin 27
- Host:
- E. coli
- Molecular Weight:
- 18/24kDa
- Protein Details:
- Interleukin-27 subunit alpha
- Purity:
- > 95%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
