IKBKB Recombinant Protein
Product Sizes
10ug
£272.00
OPCD04223-10UG
50ug
£528.00
OPCD04223-50UG
200ug
£955.00
OPCD04223-200UG
About this Product
- SKU:
- OPCD04223
- Additional Names:
- AI132552;I-kappa-B kinase 2;I-kappa-B-kinase beta;IKK;IKK-;IKK[b;IKK[b];IKK2;IKK-2;IKK-B;IKKbe;IKK-be;IKKbeta;IKK-beta;inhibitor of kappa light polypeptide gene enhancer in B-cells; kinase beta;inhibitor of nuclear factor kappa-B kinase subunit beta;NFKBIKB;nuclear factor NF-kappa-B inhibitor kinase beta;serine/threonine protein kinase IKBKB.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines; bacterial or viral products; DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn; free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response; growth control; or protection against apoptosis. In addition to the NF-kappa-B inhibitors; phosphorylates several other components of the signaling pathway including NEMO/IKBKG; NF-kappa-B subunits RELA and NFKB1; as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3; mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor. Also phosphorylates other substrates including NCOA3; BCL10 and IRS1. Within the nucleus; acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.
- Gene Details:
- inhibitor of kappaB kinase beta
- Host:
- E. coli
- Molecular Weight:
- 30kDa
- Protein Details:
- Inhibitor of nuclear factor kappa-B kinase subunit beta
- Purity:
- > 95%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
