HSPA8 Recombinant Protein
Product Sizes
10ug
£261.00
OPCD04027-10UG
50ug
£500.00
OPCD04027-50UG
200ug
£901.00
OPCD04027-200UG
About this Product
- SKU:
- OPCD04027
- Additional Names:
- Heat shock 70 kDa protein 8;heat shock cognate 70;heat shock cognate 71 kDa protein;HSC70.
- Conjugate:
- Unconjugated
- Concentration:
- 250 ug/mL (prior to lyoph)
- Extra Details:
- Molecular chaperone implicated in a wide variety of cellular processes; including protection of the proteome from stress; folding and transport of newly synthesized polypeptides; activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system; ensuring the correct folding of proteins; the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding; ATP hydrolysis and ADP release; mediated by co-chaperones. The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form; it has a low affinity for substrate proteins. However; upon hydrolysis of the ATP to ADP; it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange; which permits cycles of substrate binding and release (By similarity). May play a role in regulating apoptosis during embryonic development.
- Gene Details:
- heat shock 70kDa protein 8
- Host:
- E. coli
- Molecular Weight:
- 11kDa
- Protein Details:
- Heat shock cognate 71 kDa protein
- Purity:
- > 90%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
