HSF1 Recombinant Protein
Product Sizes
10ug
£272.00
OPCD03993-10UG
50ug
£528.00
OPCD03993-50UG
200ug
£955.00
OPCD03993-200UG
About this Product
- SKU:
- OPCD03993
- Additional Names:
- heat shock factor protein 1;Heat shock transcription factor 1;HSTF1.
- Conjugate:
- Unconjugated
- Concentration:
- 100 ug/ul (prior to lyoph)
- Extra Details:
- Function as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR); leading to the expression of a large class of molecular chaperones heat shock proteins (HSPs) that protect cells from cellular insults' damage (PubMed:1871105; PubMed:11447121; PubMed:1986252; PubMed:7760831; PubMed:7623826; PubMed:8946918; PubMed:8940068; PubMed:9341107; PubMed:9121459; PubMed:9727490; PubMed:9499401; PubMed:9535852; PubMed:12659875; PubMed:12917326; PubMed:15016915; PubMed:25963659; PubMed:26754925). In unstressed cells; is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form (PubMed:9727490; PubMed:11583998; PubMed:16278218). Upon exposure to heat and other stress stimuli; undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes (PubMed:1871105; PubMed:1986252; PubMed:8455624; PubMed:7935471; PubMed:7623826; PubMed:8940068; PubMed:9727490; PubMed:9499401; PubMed:10359787; PubMed:11583998; PubMed:12659875; PubMed:16278218; PubMed:25963659; PubMed:26754925). Activation is reversible; and during the attenuation and recovery phase period of the HSR; returns to its unactivated form (PubMed:11583998; PubMed:16278218). Binds to inverted 5'-NGAAN-3' pentamer DNA sequences (PubMed:1986252; PubMed:26727489). Binds to chromatin at heat shock gene promoters (PubMed:25963659). Plays also several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells (PubMed:9341107). Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner (PubMed:14707147). Plays a role in nuclear export of stress-induced HSP70 mRNA (PubMed:17897941). Plays a role in the regulation of mitotic progression (PubMed:18794143). Plays also a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner (PubMed:26359349). Involved in stress-induced cancer cell proliferation in a IER5-dependent manner (PubMed:26754925).
- Gene Details:
- heat shock transcription factor 1
- Host:
- E. coli
- Molecular Weight:
- 38kDa
- Protein Details:
- Heat shock factor protein 1
- Purity:
- > 90%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
