HCK Recombinant Protein
Product Sizes
10ug
£272.00
OPCD03821-10UG
50ug
£528.00
OPCD03821-50UG
200ug
£951.00
OPCD03821-200UG
About this Product
- SKU:
- OPCD03821
- Additional Names:
- AI849071;B cell/myeloid kinase;B-cell/myeloid kinase;Bmk;hematopoietic cell kinase;Hemopoietic cell kinase;p56-HCK/p59-HCK;tyrosine-protein kinase HCK.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses; including neutrophil; monocyte; macrophage and mast cell functions; phagocytosis; cell survival and proliferation; cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins; such as FCGR1A and FCGR2A; but also CSF3R; PLAUR; the receptors for IFNG; IL2; IL6 and IL8; and integrins; such as ITGB1 and ITGB2. During the phagocytic process; mediates mobilization of secretory lysosomes; degranulation; and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization; formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15; BCR; ELMO1; FCGR2A; GAB1; GAB2; RAPGEF1; STAT5B; TP73; VAV1 and WAS (By similarity).
- Gene Details:
- hemopoietic cell kinase
- Host:
- E. coli
- Molecular Weight:
- 63kDa
- Protein Details:
- Tyrosine-protein kinase HCK
- Purity:
- > 95%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
