IL6ST Recombinant Protein
Product Sizes
10ug
£272.00
OPCD03620-10UG
50ug
£528.00
OPCD03620-50UG
200ug
£955.00
OPCD03620-200UG
About this Product
- SKU:
- OPCD03620
- Additional Names:
- 5133400A03Rik;AA389424;BB405851;CD130;D13Ertd699;D13Ertd699e;gp13;gp130;IL-6 receptor subunit beta;IL-6R subunit beta;IL-6RB;IL-6R-beta;interleukin-6 receptor subunit beta;Interleukin-6 signal transducer;membrane glycoprotein 130;oncostatin-M receptor subunit alpha.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Signal-transducing molecule. The receptor systems for IL6; LIF; OSM; CNTF; IL11; CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex; which activates Janus kinases (PubMed:1602143). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:10661409). Mediates signals which regulate immune response; hematopoiesis; pain control and bone metabolism (PubMed:10661409; PubMed:26255596; PubMed:25057188; PubMed:8552649). Has a role in embryonic development (PubMed:10661409). Does not bind IL6 (By similarity). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (PubMed:10377352). Required for expression of TRPA1 in nociceptive neurons (PubMed:25057188). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (PubMed:25228504). Required for normal trabecular bone mass and cortical bone composition (PubMed:24339143; PubMed:9348227; PubMed:26255596).
- Gene Details:
- interleukin 6 signal transducer
- Host:
- E. coli
- Molecular Weight:
- 34kDa
- Protein Details:
- Interleukin-6 receptor subunit beta
- Purity:
- > 95%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
