GDF6 Recombinant Protein
Product Sizes
10ug
£268.00
OPCD03503-10UG
50ug
£517.00
OPCD03503-50UG
200ug
£933.00
OPCD03503-200UG
About this Product
- SKU:
- OPCD03503
- Additional Names:
- BMP1;BMP13;BMP-13;bone morphogenetic protein 13;GDF16;GDF-6;growth/differentiation factor 16;growth/differentiation factor 6.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map (PubMed:23307924). Required for normal formation of bones and joints in the limbs; skull; digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-specific changes in skeletal strucutres (PubMed:26774823). Seems to positively regulates differentiation of chondrogenic tissue through the growth factor receptors subunits BMPR1A; BMPR1B; BMPR2 and ACVR2A; leading to the activation of SMAD1-SMAD5-SMAD8 complex. The regulation of chondrogenic differentiation is inhibited by NOG (PubMed:12606286; PubMed:16049014). Also involved in the induction of adipogenesis from mesenchymal stem cells. This mechanism acts through the growth factor receptors subunits BMPR1A; BMPR2 and ACVR2A and the activation of SMAD1-SMAD5-SMAD8 complex and MAPK14/p38 (PubMed:23527555).
- Gene Details:
- growth differentiation factor 6
- Host:
- E. coli
- Molecular Weight:
- 16kDa
- Protein Details:
- Growth/differentiation factor 6
- Purity:
- > 95%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
