FOXA1 Recombinant Protein
Product Sizes
10ug
£268.00
OPCD03294-10UG
50ug
£522.00
OPCD03294-50UG
200ug
£940.00
OPCD03294-200UG
About this Product
- SKU:
- OPCD03294
- Additional Names:
- forkhead box protein A1;hepatocyte nuclear factor 3-alpha;HNF3A;HNF-3A;HNF-3-alpha;TCF3A;TCF-3A;transcription factor 3A.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Transcription factor that is involved in embryonic development; establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver; pancreas; lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promoter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B; alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP; albumin; tyrosine aminotransferase; PEPCK; etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis.
- Gene Details:
- forkhead box A1
- Host:
- E. coli
- Molecular Weight:
- 27kDa
- Protein Details:
- Hepatocyte nuclear factor 3-alpha
- Purity:
- > 95%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
