FGFR4 Recombinant Protein
Product Sizes
10ug
£272.00
OPCD03217-10UG
50ug
£532.00
OPCD03217-50UG
200ug
£966.00
OPCD03217-200UG
About this Product
- SKU:
- OPCD03217
- Additional Names:
- CTLA-2-beta protein;Fgfr-;Fgfr-4;fibroblast growth factor receptor 4;fibroblast growth factor receptor 4 16 minus form;protein-tyrosine kinase receptor MPK-11.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation; differentiation and migration; and in regulation of lipid metabolism; bile acid biosynthesis; glucose uptake; vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1; the rate-limiting enzyme in bile acid synthesis; in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1;4;5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2; GAB1; PIK3R1 and SOS1; and mediates activation of RAS; MAPK1/ERK2; MAPK3/ERK1 and the MAP kinase signaling pathway; as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Plays a role in postnatal lung development. May be involved in the development of skeletal muscle cell lineages.
- Gene Details:
- fibroblast growth factor receptor 4
- Host:
- E. coli
- Molecular Weight:
- 26.04kDa
- Protein Details:
- Fibroblast growth factor receptor 4
- Purity:
- > 95%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
