FBN1 Recombinant Protein
Product Sizes
10ug
£279.00
OPCD03131-10UG
50ug
£543.00
OPCD03131-50UG
200ug
£994.00
OPCD03131-200UG
About this Product
- SKU:
- OPCD03131
- Additional Names:
- AI536462;B430209H23;Fib-;Fib-1;fibrillin-1;tight skin;Tsk.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Fibrillin-1: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix; which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung; blood vessels and skin; microfibrils form the periphery of the elastic fiber; acting as a scaffold for the deposition of elastin. In addition; microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule; tendon; cornea and glomerulus where they provide tensile strength and have anchoring roles. Fibrillin-1 also plays a key role in tissue homeostasis through specific interactions with growth factors; such as the bone morphogenetic proteins (BMPs); growth and differentiation factors (GDFs) and latent transforming growth factor-beta-binding proteins (LTBPs); cell-surface integrins and other extracellular matrix protein and proteoglycan components (By similarity). Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels; respectively (PubMed:20855508). Negatively regulates osteoclastogenesis by binding and sequestering an osteoclast differentiation and activation factor TNFSF11. This leads to disruption of TNFSF11-induced Ca(2+) signaling and impairment of TNFSF11-mediated nuclear translocation and activation of transcription factor NFATC1 which regulates genes important for osteoclast differentiation and function (PubMed:24039232). Mediates cell adhesion via its binding to cell surface receptors integrins ITGAV:ITGB3 and ITGA5:ITGB1. Binds heparin and this interaction plays an important role in the assembly of microfibrils (By similarity).
- Gene Details:
- fibrillin 1
- Host:
- E. coli
- Molecular Weight:
- 27kDa
- Protein Details:
- Fibrillin-1
- Purity:
- > 97%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
