ESR1 Recombinant Protein
Product Sizes
10ug
£268.00
OPCD02962-10UG
50ug
£522.00
OPCD02962-50UG
200ug
£940.00
OPCD02962-200UG
About this Product
- SKU:
- OPCD02962
- Additional Names:
- C-terminally-truncated estrogen receptor alpha product-4;C-terminally-truncated estrogen receptor alpha product-5;C-terminally-truncated estrogen receptor alpha product-6;C-terminally-truncated estrogen receptor alpha product-7;E;ER;ER-;ER[;ERa;ERalpha;ER-alpha;Es;ESR;Estr;Estra;estradiol receptor;estrogen receptor;Nr;Nr3a1;nuclear receptor subfamily 3 group A member 1.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors; such as AP-1/c-Jun; c-Fos; ATF-2; Sp1 and Sp3; to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3.
- Gene Details:
- estrogen receptor 1 (alpha)
- Host:
- E. coli
- Molecular Weight:
- 59kDa
- Protein Details:
- Estrogen receptor
- Purity:
- > 95%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
