DDB2 Recombinant Protein
Product Sizes
10ug
£268.00
OPCD02684-10UG
50ug
£511.00
OPCD02684-50UG
200ug
£918.00
OPCD02684-200UG
About this Product
- SKU:
- OPCD02684
- Additional Names:
- 2610043A19Rik;Damage-specific DNA-binding protein 2;DNA damage-binding protein 2;p4.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD); 6-4 photoproducts (6-4 PP); apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A; histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC; which may enhance DNA-binding by XPC and promote NER.
- Gene Details:
- damage specific DNA binding protein 2
- Host:
- E. coli
- Molecular Weight:
- 28kDa
- Protein Details:
- DNA damage-binding protein 2
- Purity:
- > 95%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
