CDK8 Recombinant Protein
Product Sizes
10ug
£268.00
OPCD02105-10UG
50ug
£517.00
OPCD02105-50UG
200ug
£929.00
OPCD02105-200UG
About this Product
- SKU:
- OPCD02105
- Additional Names:
- CDK8 protein kinase;cell division protein kinase 8;cyclin-dependent kinase 8;IDDHBA;K35;mediator complex subunit CDK8;mediator of RNA polymerase II transcription subunit CDK8;protein kinase K35.
- Conjugate:
- Unconjugated
- Concentration:
- 150 ug/mL (prior to lyoph)
- Extra Details:
- Component of the Mediator complex; a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II); which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH; leading to its degradation.
- Gene Details:
- cyclin dependent kinase 8
- Host:
- E. coli
- Molecular Weight:
- 47kDa
- Protein Details:
- Cyclin-dependent kinase 8
- Purity:
- >95%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
