CD8B Recombinant Protein
Product Sizes
10ug
£294.00
OPCD02049-10UG
50ug
£587.00
OPCD02049-50UG
200ug
£1070.00
OPCD02049-200UG
About this Product
- SKU:
- OPCD02049
- Additional Names:
- Cd8b;Ly-;Ly-3;Ly-C;lymphocyte antigen 3;Lyt-;Lyt-3;T-cell membrane glycoprotein Ly-3;T-cell surface glycoprotein CD8 beta chain;T-cell surface glycoprotein Lyt-3.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells; functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn; recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited; it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production; motility; adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally; plays a critical role in thymic selection of CD8+ T-cells.
- Gene Details:
- CD8 antigen; beta chain 1
- Host:
- E. coli
- Molecular Weight:
- 21kDa
- Protein Details:
- T-cell surface glycoprotein CD8 beta chain
- Purity:
- > 95%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
