CD3D Recombinant Protein
Product Sizes
10ug
£246.00
OPCD02012-10UG
50ug
£463.00
OPCD02012-50UG
200ug
£825.00
OPCD02012-200UG
About this Product
- SKU:
- OPCD02012
- Additional Names:
- T3d;T-cell receptor T3 delta chain;T-cell surface glycoprotein CD3 delta chain.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR); TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D; CD3E; CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement; these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN; resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation; CD3D plays an essential role in thymocyte differentiation. Indeed; participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex; thymocytes are unable to differentiate properly (PubMed:10935641). Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8; which is needed for activation and positive selection of CD4 or CD8 T-cells.
- Gene Details:
- CD3 antigen; delta polypeptide
- Host:
- E. coli
- Molecular Weight:
- 11kDa
- Protein Details:
- T-cell surface glycoprotein CD3 delta chain
- Purity:
- > 95%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
